Melanie Ann Shirkey from West Viginia, lost control of her 2003 Cadillac Escalade and drove over an embankment at 6:15 p.m. on Monday.
She died at the scene.
Shirkey's 10-year-old son, Nathan, was rescued from the wreckage by members of the Spruce River Volunteer Fire Department. He was taken by a Boone County Ambulance to an awaiting helicopter, which airlifted him to CAMC General Hospital in Charleston.
He is in critical condition.
The cause of the crash is still under investigation.
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